Lipidomic Profile Revealed the Association of Plasma Lysophosphatidylcholines with Adolescent Obesity

作者：Yang Wang, Changtao Jiang, Jie‐Yun Song, Qiying Song, Jun Ma, Hai-Jun Wang · 发表于：BioMed Research International · 年份：2019 · DOI：10.1155/2019/1382418 · 被引用次数：35 · 研究领域：Metabolomics and Mass Spectrometry Studies、Diabetes, Cardiovascular Risks, and Lipoproteins、Adipose Tissue and Metabolism

Objective . The human lipidomic profile reflects lipid metabolism, including the early phase of pathophysiological changes associated with diseases. An investigation of the association between the plasma lipidomic profile and adolescent obesity might provide new insights into the biological mechanisms of obesity. Therefore, we aimed to investigate the association of the plasma lipidome with obesity in Chinese adolescents using lipidomics. Methods . Using a combination of liquid chromatography and electrospray ionization tandem mass spectrometry, we quantified 328 lipid species from 24 lipid classes and subclasses in 100 male adolescents aged 14–16 years who were categorized into four groups: (1) normal weight with traditional normal clinical plasma lipid levels (NN); (2) normal weight with traditional abnormal clinical plasma lipid levels (NA); (3) obese with traditional normal clinical plasma lipid levels (ON); and (4) obese with traditional abnormal clinical plasma lipid levels (OA). The concentrations of all the lipid species were compared between obese and normal-weight adolescents at different traditional clinical plasma lipid levels using the Kruskal–Wallis test followed by the Mann–Whitney U test. A partial least squares discriminant analysis (PLS-DA) was applied to select lipids with a significant ability to discriminate adolescent obesity. Results . The lipidomic profile distinguished obese adolescents from normal-weight subjects. Regardless of whether traditional cl...