Honokiol Ameliorates High-Fat-Diet-Induced Obesity of Different Sexes of Mice by Modulating the Composition of the Gut Microbiota

作者：Yanan Ding, Zehe Song, Hao Li, Ling Chang, Tingli Pan, Xueling Gu, Xi He, Zhiyong Fan · 发表于：Frontiers in Immunology · 年份：2019 · DOI：10.3389/fimmu.2019.02800 · 被引用次数：61 · 研究领域：Gut microbiota and health、Magnolia and Illicium research、Tryptophan and brain disorders

Background Accumulating data support the fact that the gut microbiota plays an important role in the progression of obesity and its related metabolic disease. Sex-related differences are an important consideration in the study of gut microbiota. Polyphenols can regulate gut microbiota, thereby improving obesity and its associated complications. Honokiol(HON), which extract from Chinese herbal medicine, has no studies conducted on its ability to regulate gut microbiota. The aim of this study was to examine whether honokiol (HON) supplementation would improve obesity by regulating the gut microbiota and its related metabolite levels, and whether there were sex-based differences in high-fat diet-induced obese mice. Methods C57BL/6 mice (n=120) were fed a normal chow diet (ND), high-fat diet (HFD), or HFD plus HON at 0.02%, 0.04%, and 0.08% for 8 weeks. Body weight, adipose tissue weight, adipocyte diameter, insulin resistance, blood lipid and serum inflammatory cytokines, gut microbiota and its metabolite were examined at the end of the experiment. Rsults The HON supplementation reduced body weight, adipose tissue weight, adipocyte diameter, insulin resistance, blood lipid and serum inflammatory cytokines levels in HFD-fed mice, and this effect was significant in high dose group. In addition, HON not noly reversed gut disorders in HFD-fed mice, such as by enhanced the abundance of Akkermansia and short-chain fatty acids (SCFAs) producing Bacteroides and reduced Oscillospira but ...