Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

作者：Ramon Subirós‐Funosas, Vivian Cheuk Lam Ho, Nicole D. Barth, Lorena Mendive‐Tapia, Morena Pappalardo, Xavier Barril, Ruoyu Ma, Chengbin Zhang, Bin‐Zhi Qian, Miquel Sintes, Ouldouz Ghashghaei, Rodolfo Lavilla, Marc Vendrell · 发表于：Chemical Science · 年份：2019 · DOI：10.1039/c9sc05558d · 被引用次数：62 · 研究领域：Skin and Cellular Biology Research、Fibroblast Growth Factor Research、Silk-based biomaterials and applications

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.