Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms

作者：Craig D. Shimasaki, Richard E. Frye, Rosario Rich Trifiletti, Michael S. Cooperstock, Gary Kaplan, Isaac Melamed, Rosalie Greenberg, Amiram Katz, Eric Fier, David C. Kem, David J. Traver, Tania T. Dempsey, Maya Latimer, Amy Rachael Cross, Joshua P. Dunn, Rebecca Bentley, Kathy M Alvarez, Sean Reim, James Richard Appleman · 发表于：Journal of Neuroimmunology · 年份：2019 · DOI：10.1016/j.jneuroim.2019.577138 · 被引用次数：60 · 研究领域：Obsessive-Compulsive Spectrum Disorders、Autoimmune Neurological Disorders and Treatments、Tryptophan and brain disorders

Objective This retrospective study examined whether changes in patient pre- and post-treatment symptoms correlated with changes in anti-neuronal autoantibody titers and the neuronal cell stimulation assay in the Cunningham Panel in patients with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS), and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). Methods In an analysis of all tests consecutively performed in Moleculera Labs' clinical laboratory from April 22, 2013 to December 31, 2016, we identified 206 patients who were prescribed at least one panel prior to and following treatment, and who met the PANDAS/PANS diagnostic criteria. Patient follow-up was performed to collect symptoms and treatment or medical intervention. Of the 206 patients, 58 met the inclusion criteria of providing informed consent/assent and documented pre- and post-treatment symptoms. Clinician and parent-reported symptoms after treatment or medical intervention were categorized as "Improved/Resolved" ( n = 34) or "Not-Improved/Worsened" ( n = 24). These were analyzed for any association between changes in clinical status and changes in Cunningham panel test results. Clinical assay performance was also evaluated for reproducibility and reliability. Results Comparison of pre- and post-treatment status revealed that the Cunningham Panel results correlated with changes in patient's neuropsychiatric symptoms. Based upon the change in the number of positive...