An Oxygen Self‐Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment

作者：Wei Jiang, Xiaoxue Han, Taixing Zhang, Diya Xie, Hao Zhang, Yong Hu · 发表于：Advanced Healthcare Materials · 年份：2019 · DOI：10.1002/adhm.201901303 · 被引用次数：54 · 研究领域：Radiation Therapy and Dosimetry、Nanoplatforms for cancer theranostics、Cancer, Hypoxia, and Metabolism

Abstract The hypoxia‐induced resistance to radiotherapy (RT) is a great threat to cancer patients. Therefore, overcoming the hypoxia tumor microenvironment is a vital issue. Herein, spindle‐shaped CuS@CeO 2 core–shell nanoparticles combining self‐supplied oxygen, photothermal ability, and RT sensitive to cancer therapy are introduced. The spindle shape of CuS@CeO 2 core–shell nanoparticles can potentiate their tumor penetration and subsequent internalization by cancer cells. The presence of CeO 2 , functioning as a nanoenzyme, catalyzes the endogenous H 2 O 2 in tumor tissue into O 2 , which remodels the hypoxic microenvironment into one susceptible to RT. CuS nanoparticles encapsulated in CeO 2 undergo a steady release and deep tumor penetration, allowing the regression of lesions less affected by RT. Furthermore, in vitro and in vivo studies reveal that the design not only mitigates the dosage of RT, but more importantly allows the entire tumor to be treated without relapses.