The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey

作者：Jianfeng Xie, Hongliang Wang, Yan Kang, Lixin Zhou, Zhongmin Liu, Bingyu Qin, Xiaochun Ma, Xiangyuan Cao, Dechang Chen, Weihua Lü, Chen Yao, Kaijiang Yu, Xiaoqing Yao, Hongcai Shang, Haibo Qiu, Yi Yang · 发表于：Critical Care Medicine · 年份：2019 · DOI：10.1097/ccm.0000000000004155 · 被引用次数：510 · 研究领域：Sepsis Diagnosis and Treatment、Nosocomial Infections in ICU、Neonatal and Maternal Infections

OBJECTIVES: We performed a national cross-sectional survey to determine the epidemiologic characteristics of patients with sepsis in ICU in China. DESIGN: A cross-section survey study. SETTING: Forty-four hospitals in mainland China from December 1, 2015, to January 31, 2016. PATIENTS: All septic patients diagnosed according sepsis-1 criteria admitted to participating ICU. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We recorded demographic, physiologic, and microbiological data with follow-up for 90 days or death, if sooner. The frequency of sepsis and 90-day mortality rate were computed, and the relationship with gross domestic product determined. Multivariate logistic regression analysis was used to determine risk factors for 90-day mortality in patients with sepsis. Two-thousand three-hundred twenty-two patients with sepsis were included in the analysis, of whom 786 patients (33.9%) had hospital-acquired sepsis. The most common infection site was the lung (68.2%), followed by abdomen (26.6%) and bloodstream (7.8%). The frequency of sepsis in the ICU was 20.6 cases per 100 ICU admissions (95% CI, 15.8-25.4) with a 90-day mortality of 35.5%. The proportion of sepsis, severe sepsis, and septic shock were 3.10%, 43.6%, and 53.3% with a 90-day mortality of 2.78%, 17.69%, and 51.94%, respectively. Older age, low body weight, higher Sequential Organ Failure Assessment score, the number of systemic inflammatory response syndrome criteria, comorbid with heart failure, hemat...