Surgical treatment to multiple primary lung cancer patients: a systematic review and meta-analysis

作者：Ting-Fei Chen, Chun-Ying Xie, Bing-Yu Rao, Shi-Chao Shan, Xin Zhang, Bo Zeng, Yi-Yan Lei, Honghe Luo · 发表于：BMC Surgery · 年份：2019 · DOI：10.1186/s12893-019-0643-0 · 被引用次数：69 · 研究领域：Lung Cancer Diagnosis and Treatment、Multiple and Secondary Primary Cancers、Lung Cancer Research Studies

BACKGROUND: As there is no consensus on the optimal surgery strategy for multiple primary lung cancer (MPLC), we conducted this study to address this issue by comparing the prognosis of MPLC patients underwent different surgical strategies including sublobar resection and the standard resection through a systemic review and meta-analysis. METHODS: Relevant literature was obtained from three databases including PubMed, Embase and Web of Science. Inclusion and exclusion criteria were set for the screening of articles to be selected for further conduction of systemic review and meta-analysis. The HRs of OS of the sublobar group compared with standard resection group were extracted directly or calculated indirectly from included researches. RESULTS: Ten researches published from 2000 to 2017 were included in this study, with 468 and 445 MPLC cases for the standard resection group and sublobar resection group respectively. The result suggested that OS of MPLC patients underwent sublobar resection (segmentectomy or wedge resection for at least one lesion) was comparable with those underwent standard resection approach (lobectomy or pneumonectomy for all lesions), with HR 1.07, 95% CI 0.67-1.71, p = 0.784. Further analysis found no difference in subgroups of synchronous and metachronous (from second metachronous lesion), different population region and dominant sex type. CONCLUSIONS: This study may reveal that sublobar resection is acceptable for patients with MPLC at an early stage...