A microfluidic organotypic device for culture of mammalian intestines ex vivo

作者：Alec Richardson, Luke Schwerdtfeger, Diana Eaton, Ian C. McLean, Charles S. Henry, Stuart Tobet · 发表于：Analytical Methods · 年份：2019 · DOI：10.1039/c9ay02038a · 被引用次数：33 · 研究领域：3D Printing in Biomedical Research、Clinical Nutrition and Gastroenterology、Microfluidic and Capillary Electrophoresis Applications

A microfluidic organotypic device that maintains mouse colon explants for up to 72 h in a physiologically relevant environment is reported. The device is easy to assemble and maintains physiologically accurate oxygen concentrations across the tissue.