An Update on Early Urological Complications in Kidney Transplantation: A National Cohort Study

作者：Moira H. D. Bruintjes, Frank d’Ancona, Xiaoye Zhu, Andries J. Hoitsma, Michiel C. Warlé · 发表于：Annals of Transplantation · 年份：2019 · DOI：10.12659/aot.920086 · 被引用次数：29 · 研究领域：Renal and Vascular Pathologies、Organ Donation and Transplantation、Renal Transplantation Outcomes and Treatments

BACKGROUND This study aimed to provide an update on the occurrence of early urological complications in living-donor and deceased-donor kidney transplantation (KTX). MATERIAL AND METHODS Data on all kidney transplant recipients in the Netherlands between January 2005 and December 2015 were retrieved from the prospectively collected Dutch National Organ Transplant Registry Database (NOTR). We assessed the incidence of major urological complications (MUCs) within 3 months after KTX, defined as urinary leakage and ureteral obstruction. Outcomes of living donor and deceased donor kidney transplants were compared. We performed regression analysis to identify predictive factors of urological complications and studied the influence of early urological complications on graft and patient survival. We performed an additional sub-study to explore the influence of preservation of the peri-ureteric connective tissue in living-donor KTX on the occurrence of urological complications. RESULTS Among 3329 kidney transplant recipients, urological complications occurred in 208 patients (6.2%) within 3 months after surgery. There were no significant differences in complication rates between recipients from living donors and deceased donors. Multiple regression analysis showed that older donor age and previous cardiac events of the recipient were predictors for the development of urological complications. Graft and patient survival were not affected by early MUCs. The additional sub-study sho...