<p>Overview of microRNA-199a Regulation in Cancer</p>

作者：Qiwen Wang, Bingyu Ye, Ping Wang, Fenjie Yao, Chunyan Zhang, Guoying Yu · 发表于：Cancer Management and Research · 年份：2019 · DOI：10.2147/cmar.s231971 · 被引用次数：73 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、Autophagy in Disease and Therapy

microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.