Prognostic Significance of Serum Uric Acid and Gamma-Glutamyltransferase in Patients with Advanced Gastric Cancer

作者：Shanshan Yang, Xinjia He, Ying Liu, Xiao Ding, Haiping Jiang, Ye Tan, Haijun Lu · 发表于：Disease Markers · 年份：2019 · DOI：10.1155/2019/1415421 · 被引用次数：34 · 研究领域：Gout, Hyperuricemia, Uric Acid、Sulfur Compounds in Biology、Liver Disease Diagnosis and Treatment

Purpose . In this study, we aim to evaluate the prognostic role of serum uric acid and gamma-glutamyltransferase in advanced gastric cancer patients. Methods . A total of 180 patients pathologically diagnosed with advanced gastric cancer were included in this retrospective study. We used time-dependent receiver operating characteristic (ROC) curves to identify the optimal cut-off value of serum uric acid (UA) and gamma-glutamyltransferase (GGT). Survival analysis was performed using the Kaplan–Meier method and log-rank test, and multivariate Cox regression analyses were applied. A nomogram was formulated, and the calibration and discrimination of the nomogram were determined by calibration curve and concordance index (C-index). We validated the results using bootstrap resampling and a separate study on 60 patients collected from 2015 to 2017 using the same criteria in other medical center. Results . Both higher serum uric acid (>228 μ mol/L) and higher gamma-glutamyltransferase (>14 U/L) had worse OS and PFS. Univariate analysis indicated that serum uric acid (UA) ( p < 0.001 and p < 0.001 ) and gamma-glutamyltransferase (GGT) ( p < 0.001 and p = 0.044 ) were significantly related to overall survival (OS) and progression-free survival (PFS), respectively. Multivariate analysis revealed serum uric acid (UA) and gamma-glutamyltransferase (GGT) were independent prognostic factors for OS ( p = 0.012 , p = 0.001 ). The optimal agreement ...