Mechanical Roles in Formation of Oriented Collagen Fibers

作者：Jiexiang Lin, Yan‐Ping Shi, Yutao Men, Xin Wang, Jinduo Ye, Chunqiu Zhang · 发表于：Tissue Engineering Part B Reviews · 年份：2019 · DOI：10.1089/ten.teb.2019.0243 · 被引用次数：98 · 研究领域：Tendon Structure and Treatment、Collagen: Extraction and Characterization、Cellular Mechanics and Interactions

Collagen is a structural protein that is widely present in vertebrates, being usually distributed in tissues in the form of fibers. In living organisms, fibers are organized in different orientations in various tissues. As the structural base in connective tissue and load-bearing tissue, the orientation of collagen fibers plays an extremely important role in the mechanical properties and physiological and biochemical functions. The study on mechanics role in formation of oriented collagen fibers enables us to understand how discrete cells use limited molecular materials to create tissues with different structures, thereby promoting our understanding of the mechanism of tissue formation from scratch, from invisible to tangible. However, the current understanding of the mechanism of fiber orientation is still insufficient. In addition, existing fabrication methods of oriented fibers are varied and involve interdisciplinary study, and the achievements of each experiment are favorable to the construction and improvement of the fiber orientation theory. To this end, this review focuses on the preparation methods of oriented fibers and proposes a model explaining the formation process of oriented fibers in tendons based on the existing fiber theory. Impact statement As the structural base in connective tissue and load-bearing tissue, the orientation of collagen fibers plays an extremely important role in the mechanical properties and physiological and biochemical functions. However...