FgAP‐2 complex is essential for pathogenicity and polarised growth and regulates the apical localisation of membrane lipid flippases in Fusarium graminearum

作者：Jing Zhang, Yingzi Yun, Yi Lou, Yakubu Saddeeq Abubakar, Pusheng Guo, Shumin Wang, Chunling Li, Yuan Feng, Muhammad Adnan, Jie Zhou, Guodong Lu, Wenhui Zheng · 发表于：Cellular Microbiology · 年份：2019 · DOI：10.1111/cmi.13041 · 被引用次数：20 · 研究领域：Plant Reproductive Biology、Polysaccharides and Plant Cell Walls、Fungal and yeast genetics research

) of the FgAP-2 complex significantly affects the fungal vegetative growth, conidial morphology, and germination. Remarkably, FgAP-2 complex is important for the fungal pathogenicity, especially during colonisation and extension after infecting the host. The FgAP-2 complex is expressed ubiquitously at all developmental stages but having more concentrated protein distribution at the subapical collar and septa in young growing hyphae. Although FgAP-2 complex displays similar dynamic behaviour to the actin patch components and accumulates at endocytic sites, it is dispensable for general endocytosis. We further demonstrated that FgAP-2 complex is required for polar localisation of the lipid flippases FgDnfA and FgDnfB, which led to the proposal that FgAP-2 functions as a cargo-specific adaptor that promotes polar growth and colonising ability of F. graminearum.