Relay Rh( ii )/Pd(0) dual catalysis: synthesis of α-quaternary β-keto-esters via a [1,2]-sigmatropic rearrangement/allylic alkylation cascade of α-diazo tertiary alcohols

作者：Xian-Xu Wang, Xiaoyan Huang, Sen-Hao Lei, Fang Yang, Jin‐Ming Gao, Ke‐Gong Ji, Zi‐Sheng Chen · 发表于：Chemical Communications · 年份：2019 · DOI：10.1039/c9cc08559a · 被引用次数：19 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis

A relay Rh(ii)/Pd(0) dual catalysis that enables domino [1,2]-sigmatropic rearrangement/allylic alkylation of α-diazo tertiary alcohols is described. This transformation represents a highly efficient method for the one-pot synthesis of α-quaternary β-keto-esters under mild conditions, in which two separate C-C σ-bonds at the carbenic center were formed in a straightforward manner.