EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees

作者：Alan Horwich, Marek Babjuk, Joaquim Bellmunt, Harman Maxim Bruins, Theo M. de Reijke, Maria De Santis, Silke Gillessen, Nicholas David James, Steven J. MacLennan, Juan Palou, Tom Powles, María José Ribal, Shahrokh François Shariat, Theodorus van der Kwast, Evanguelos N. Xylinas, Nishtha Agarwal, T.J.H. Arends, Aristotle Bamias, Alison Jane Birtle, Peter C. Black, Bernard H. Bochner, M. Bolla, Joost L. Boormans, Alberto Bossi, Alberto Briganti, Iris S. G. Brummelhuis, Max M. Burger, Daniel Castellano, Richard L. Cathomas, Arturo Chiti, Ananya Choudhury, Éva Compérat, Simon J. Crabb, Stéphane Culine, Berardino De Bari, W. DeBlok, Pieter J. L. De Visschere, Karel Decaestecker, Konstantinos Dimitropoulos, J.L. Domínguez-Escrig, Stefano Fanti, Valérie Fonteyne, Mark Frydenberg, Jurgen Jacobus Fütterer, Georgios Gakis, Bogdan Florin GEAVLETE, Paolo Gontero, Bernhard Grubmüller, Shaista Hafeez, Donna Elizabeth Hansel, Arndt Hartmann, Dickon Hayne, Ann M. Henry, Virginia Hernández, H.W. Herr, Ken Herrmann, Peter Hoskin, Jorge Huguet, Barbara Alicja Jereczek‐Fossa, Rob Jones, Ashish M. Kamat, Vincent S Khoo, Anne E. Kiltie, S. Krege, Sylvain Ladoire, Pedro C. Lara, Anna M. Leliveld, Estefanía Linares-Espinós, Vibeke Løgager, Anja Lorch, Yohann Loriot, Richard Paul Meijer, Maria Carmen Mir, Marco Moschini, Hugh A. Mostafid, Arndt‐Christian Müller, C Müller, James MO N'Dow, Andrea Necchi, Y. Neuzillet, Jorg Reinier Oddens, Jan Oldenburg, Susanne Osanto, Wim J.G. Oyen, Luís Pacheco‐Figueiredo, Helle Pappot, Manish I. Patel, Bradley Rumwell Pieters, Karin Plass, Mesut Remzi, Margitta M. Retz, Jonathan Richenberg, Michael Rink, Florian Roghmann, Jonathan E. Rosenberg, Morgan Rouprêt, Olivier Rouvière, Carl Salembier, Antti Salminen, Paul Sargos, Shomik Sengupta, Amir M. Sherif, Robert Jan Smeenk, Armand Smits, Arnulf Stenzl, George Niklaus Thalmann, Bertrand F. TOMBAL, Barış Türkbey, Susanne Vahr Lauridsen, R. Valdagni, Antoine G. van der Heijden, Hendrik Van Poppel, Mihai Dorin Vartolomei, Erik Veskimäe, Antoni Vilaseca, Franklin A. Vives Rivera, Thomas Wiegel, Peter N. Wiklund, Anna Williams, Richard E. Zigeuner, Johannes Alfred Witjes · 发表于：Annals of Oncology · 年份：2019 · DOI：10.1093/annonc/mdz296 · 被引用次数：183 · 研究领域：Bladder and Urothelial Cancer Treatments、Delphi Technique in Research、Esophageal Cancer Research and Treatment

BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference. SETTING: Online Delphi survey and consensus conference. PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus). RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus....