Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

作者：Arun Kumar Ghosh, Margherita Brindisi · 发表于：Journal of Medicinal Chemistry · 年份：2019 · DOI：10.1021/acs.jmedchem.9b01541 · 被引用次数：393 · 研究领域：Eicosanoids and Hypertension Pharmacology、Pharmacogenetics and Drug Metabolism、Synthesis and Catalytic Reactions

The urea functionality is inherent to numerous bioactive compounds, including a variety of clinically approved therapies. Urea containing compounds are increasingly used in medicinal chemistry and drug design in order to establish key drug-target interactions and fine-tune crucial drug-like properties. In this perspective, we highlight physicochemical and conformational properties of urea derivatives. We provide outlines of traditional reagents and chemical procedures for the preparation of ureas. Also, we discuss newly developed methodologies mainly aimed at overcoming safety issues associated with traditional synthesis. Finally, we provide a broad overview of urea-based medicinally relevant compounds, ranging from approved drugs to recent medicinal chemistry developments.