NDUFA4 enhances neuron growth by triggering growth factors and inhibiting neuron apoptosis through Bcl-2 and cytochrome C mediated signaling pathway.

作者：Fang Fu, Yan Li, Ru Li, Tingying Lei, Dan Wang, Xin Yang, Jin Han, Min Pan, Zhen Li, Yanmei Ou, Jian Li, Fao-Tao Li, Xiangyi Jing, Dong‐Zhi Li, Can Liao · 发表于：PubMed · 年份：2018 · 被引用次数：8 · 研究领域：Fetal and Pediatric Neurological Disorders、Prenatal Screening and Diagnostics、Cancer-related molecular mechanisms research

<0.05). NDUFA4 up-regulated growth factors, including NGF, BDNF, bFGF and Cyt C and inhibited Cyt C expression. NDUFA4 interfere inhibits antagonistic effect of ciclosporin A on apoptosis and decrease up-regulative effect of ciclosporin A on neuron growth. NDUFA4 over-expression enhances antagonistic effect of ciclosporin A on apoptosis and increases up-regulative effect of ciclosporin A on neuron growth. In conclusion, NDUFA4 enhances neuron growth by triggering NGF, BDNF and bFGF expression, inhibits neuron apoptosis by increasing Bcl-2 expression and decreasing cyto C expression. Meanwhile, NDUFA4 regulates the antagonistic effect of ciclosporin A on apoptosis and the up-regulative effect of ciclosporin A on neuron growth.