Brain–kidney interaction: Renal dysfunction following ischemic stroke

作者：Qiang Zhao, Tao Yan, Michael Chopp, Poornima Venkat, Jieli Chen · 发表于：Journal of Cerebral Blood Flow & Metabolism · 年份：2019 · DOI：10.1177/0271678x19890931 · 被引用次数：109 · 研究领域：Neurological Complications and Syndromes、Renal and Vascular Pathologies、Acute Kidney Injury Research

Stroke is a leading cause of mortality and morbidity, with long-term debilitating effects. Accumulating evidence from experimental studies as well as observational studies in patients suggests a cross talk between the brain and kidney after stroke. Stroke may lead to kidney dysfunction which can adversely impact patient outcome. In this review article, we discuss the epidemiology and mechanisms of brain–kidney interaction following ischemic stroke. Specifically, we discuss the role of the central autonomic network, autoregulation, inflammatory and immune responses, the role of extracellular vesicles and their cargo microRNA, in mediating brain–kidney interaction following stroke. Understanding the bidirectional nature of interaction between the brain and kidney after cerebral injury would have clinical implications for the treatment of stroke and overall patient outcome.