Enantioselective Radical Ring-Opening Cyanation of Oxime Esters by Dual Photoredox and Copper Catalysis

作者：Jun Chen, Jun Chen, Peng‐Zi Wang, Bin Lu, Dong Liang, Xiaoye Yu, Wen‐Jing Xiao, Jia‐Rong Chen, Jia‐Rong Chen · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b03970 · 被引用次数：85 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Catalytic enantioselective chemical reactions involving highly reactive radical species remain largely unexplored. We report herein for the first time a novel enantioselective radical ring-opening cyanation of redox-active oxime esters by dual photoreodox and copper catalysis. This mild protocol shows good functional group tolerance and broad substrate scope, producing a wide range of optically active alkyl dinitriles with high yields and excellent enantioselectivities, which are difficult to access traditionally.