Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

作者：Zongjing Xie, Bingmei Wang, Yongjie Chai, Junyin Chen · 发表于：Journal of Clinical Pathology · 年份：2019 · DOI：10.1136/jclinpath-2019-206189 · 被引用次数：21 · 研究领域：Helicobacter pylori-related gastroenterology studies、Glutathione Transferases and Polymorphisms、Glycosylation and Glycoproteins Research

AIMS: and GC by combing the results of all relevant studies. METHODS: Eligible studies were searched from PubMed, Embase, WOS and CNKI. We used Review Manager to combine the results of individual studies. RESULTS: rs2274223 (dominant comparison: OR: 0.84, 95 % CI: 0.72 to 0.98; recessive comparison: OR: 1.23, 95 % CI: 1.08 to 1.40; over-dominant comparison: OR: 1.16, 95 % CI: 1.00 to 1.34; allele comparison: OR 0.88, 95 % CI 0.78 to 0.99) polymorphisms were significantly associated with GC in the general population. We also obtained similar significant associations with GC for rs5742909 and rs2274223 polymorphisms in East Asians. Nevertheless, no positive results were observed for the other eight investigated polymorphisms. CONCLUSION: rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.