Peroxide-mediated site-specific C–H methylation of imidazo[1,2- a ]pyridines and quinoxalin-2(1 H )-ones under metal-free conditions

作者：Shengzhou Jin, Hua Yao, Sen Lin, Xiaoqing You, Yao Yang, Zhaohua Yan · 发表于：Organic & Biomolecular Chemistry · 年份：2019 · DOI：10.1039/c9ob02328c · 被引用次数：43 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Biological Evaluation、Cyclopropane Reaction Mechanisms

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described. In this protocol, peroxides serve as both the radical initiator and methyl source. Methylated imidazopyridines and quinoxalin-2(1H)-ones were smoothly synthesized in moderate to good yields. A free radical reaction mechanism was proposed to describe the methylation process.