Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia

作者：Eryan Yang, Ying Cai, Xiuhua Yao, Ji Liu, Qixue Wang, Weili Jin, Qiaoli Wu, Weijia Fan, Lina Qiu, Chunsheng Kang, Jialing Wu · 发表于：Aging · 年份：2019 · DOI：10.18632/aging.102431 · 被引用次数：31 · 研究领域：Barrier Structure and Function Studies、Acute Ischemic Stroke Management、Neurological Disease Mechanisms and Treatments

. Rt-PA did not decrease TGF-β and p-Smad2/3 expression in PDGFR-β-overexpressing pericytes after OGD. These findings identify PDGFR-β/TGF-β/p-Smad2/3 signaling in pericytes as a new therapeutic target for the treatment of rt-PA-induced BBB damage.