Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

作者：Patrick Kee, Melanie R. Moody, Shaoling Huang, Hyunggun Kim, Xing Yin, Tao Peng, Susan T. Laing, Melvin E. Klegerman, Mohammad H. Rahbar, Deborah Vela, Curtis Genstler, Kevin J. Haworth, Christy K. Holland, David D. McPherson · 发表于：JACC Basic to Translational Science · 年份：2019 · DOI：10.1016/j.jacbts.2019.09.005 · 被引用次数：18 · 研究领域：Coronary Interventions and Diagnostics、Angiogenesis and VEGF in Cancer、Electrospun Nanofibers in Biomedical Applications

Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide-loaded echogenic liposomes (ELIPs) and anti-intercellular adhesion molecule-1 conjugated ELIPs loaded with pioglitazone exposed to an endovascular catheter with an ultrasonic core. Ultrasound-facilitated delivery of ELIP formulations into stented peripheral arteries attenuated neointimal growth. Local atheroma-targeted, ultrasound-triggered delivery of nitric oxide and pioglitazone, an anti-inflammatory peroxisome proliferator-activated receptor-γ agonist, into stented arteries has the potential to stabilize stent-induced neointimal growth and obviate the need for long-term antiplatelet therapy.