Abnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohorts

作者：Sanne K. Meles, Remco J. Renken, Marco Pagani, Laura K. Teune, Dario Arnaldi, Silvia Daniela Morbelli, Flavio Mariano Nobili, Teus van Laar, Jose Angel Obeso, María Cruz Rodríguez-Oroz, Klaus Leonhard Leenders · 发表于：European Journal of Nuclear Medicine and Molecular Imaging · 年份：2019 · DOI：10.1007/s00259-019-04570-7 · 被引用次数：102 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological disorders and treatments、Metabolism, Diabetes, and Cancer

Abstract Rationale In Parkinson’s disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a further validation of the PDRP by applying spatial covariance analysis to PD cohorts from the Netherlands (NL), Italy (IT), and Spain (SP). Methods The PDRPNL was previously identified (17 controls, 19 PD) and its expression was determined in 19 healthy controls and 20 PD patients from the Netherlands. The PDRPIT was identified in 20 controls and 20 “de-novo” PD patients from an Italian cohort. A further 24 controls and 18 “de-novo” Italian patients were used for validation. The PDRPSP was identified in 19 controls and 19 PD patients from a Spanish cohort with late-stage PD. Thirty Spanish PD patients were used for validation. Patterns of the three centers were visually compared and then cross-validated. Furthermore, PDRP expression was determined in 8 patients with multiple system atrophy. Results A PDRP could be identified in each cohort. Each PDRP was characterized by relative hypermetabolism in the thalamus, putamen/pallidum, pons, cerebellum, and motor cortex. These changes co-varied with variable degrees of hypometabolism in posterior parietal, occipital, and frontal cortices. Frontal hypometabolism was less pronounced in “de-novo” PD subjects (Ita...