Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?

作者：Mattia Sponchioni, Cate T. O’Brien, Christina E. Borchers, E. Wang, Marcelo N. Rivolta, Nicholas J. W. Penfold, Irene Cantón, Steven P. Armes · 发表于：Chemical Science · 年份：2019 · DOI：10.1039/c9sc04734d · 被引用次数：28 · 研究领域：Pluripotent Stem Cells Research、3D Printing in Biomedical Research、Tissue Engineering and Regenerative Medicine

It is shown that hydroxyl functionality is required to induce stasis in human embryonic stem cell colonies immersed within wholly synthetic block copolymer worm gels with comparable storage moduli. Thus gel softness does not appear to be an essential parameter for stasis induction.