Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft

作者：Yuling Chen, Lucy Lu, Ying Wu, Shen Yu-zhi, Haibo Zhao, Shu Ding, Xinwei Feng, Li Sun, Xiangjun Tao, Jinglian Li, Ruiying Ma, Weiwei Liu, Fangqin Wu, Yadi Feng · 发表于：American Journal of Critical Care · 年份：2019 · DOI：10.4037/ajcc2019976 · 被引用次数：52 · 研究领域：Intensive Care Unit Cognitive Disorders、Thermal Regulation in Medicine、Enhanced Recovery After Surgery

BACKGROUND: Serum level of interleukin 6 (IL-6) is known to be associated with postoperative delirium. However, no consensus has emerged on the postoperative time point at which IL-6 level may predict postoperative delirium after coronary artery bypass graft surgery. OBJECTIVES: To compare trends in IL-6 levels in patients with and without postoperative delirium and to examine the relationship between IL-6 levels at different times and postoperative delirium after coronary artery bypass graft. METHODS: A prospective cohort study of patients who underwent their first elective isolated coronary artery bypass graft between November 2013 and August 2015 at a cardiac intensive care unit in Beijing, China. Concentrations of IL-6 were measured before the operation and at the 6th, 12th, and 18th postoperative hours. Participants were assessed for postoperative delirium twice daily for 5 days. Univariate and multivariate logistic regression analyses were done to determine associations between IL-6 levels at different time points, postoperative changes in IL-6 levels, and the occurrence of postoperative delirium. RESULTS: = .002) were associated with higher incidence of postoperative delirium. CONCLUSION: Interleukin 6 level (≥ 583 pg/mL) at the 18th postoperative hour may serve as a potent predictor of postoperative delirium in coronary artery bypass graft patients.