The role of interleukin-17 in tumor development and progression

作者：Junjie Zhao, Xing Chen, Tomasz Herjan, Xiaoxia Li · 发表于：The Journal of Experimental Medicine · 年份：2019 · DOI：10.1084/jem.20190297 · 被引用次数：254 · 研究领域：Psoriasis: Treatment and Pathogenesis、Cancer Immunotherapy and Biomarkers、Cytokine Signaling Pathways and Interactions

IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate IL-17 as a link among inflammation, wound healing, and cancer. While IL-17-mediated production of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigenesis. Here, we review the pleotropic impacts of IL-17 on cancer biology, focusing how IL-17-mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-promoting function and discussing the implications in therapies.