Iron and magnetic: new research direction of the ferroptosis-based cancer therapy.

作者：Shenghang Wang, Jie Luo, Zhihao Zhang, Dandan Dong, Ying Shen, Yanwen Fang, Lijiang Hu, Mengyu Liu, Chengfu Dai, Songlin Peng, Zhicai Fang, Peng Shang · 发表于：PubMed · 年份：2018 · 被引用次数：118 · 研究领域：Ferroptosis and cancer prognosis、Trace Elements in Health、Heme Oxygenase-1 and Carbon Monoxide

) in acidic lysosomes and inducing ferroptosis. Magnetic field is widely used in the targeted concentration of iron-based NPs related disease therapy. Furthermore, multiple studies showed that magnetic fields can inhibit cancer cell proliferation by promoting intracellular ROS production. Herein, we focus on the relationship of between ferroptosis and iron metabolism in cancer cells, the application of nanoparticles and magnetic field in inducing ferroptosis of cancer cells, and trying to provide new ideas for cancer treatment research.