Targeting the interleukin-17 immune axis for cancer immunotherapy

作者：Gerardo A. Vitiello, George Miller · 发表于：The Journal of Experimental Medicine · 年份：2019 · DOI：10.1084/jem.20190456 · 被引用次数：151 · 研究领域：Cancer Immunotherapy and Biomarkers、Psoriasis: Treatment and Pathogenesis、Immunotherapy and Immune Responses

The role of IL-17 in cancer remains controversial. Emerging evidence suggests that during early oncogenesis IL-17 supports tumor growth, whereas in established tumors IL-17 production by γδ and Th17 cells potentiates antitumor immunity. Consequently, γδ and Th17 cells are attractive targets for immunotherapy in the IL-17 immune axis. To optimize IL-17-based immunotherapy, a deeper understanding of the cytokines dictating IL-17 production and the polarity of γδ and Th17 cells is critical. Here, we delve into the dichotomous roles of IL-17 in cancer and provide insight into the tumor microenvironment conducive for successful IL-17-based γδ and Th17 cell immunotherapy.