Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

作者：Jongha Lee, Hye Rim Cho, Gi Doo, Hyunseon Seo, Seunghyun Lee, Chul‐Kee Park, Jin Wook Kim, Shutao Qiao, Liu Wang, Dayoung Kang, Taegyu Kang, Tomotsugu Ichikawa, Jonghoon Kim, Hak-Yong Lee, Woongchan Lee, Sanghoek Kim, Soon‐Tae Lee, Nanshu Lu, Taeghwan Hyeon, Seung Hong Choi, Dae‐Hyeong Kim · 发表于：Nature Communications · 年份：2019 · DOI：10.1038/s41467-019-13198-y · 被引用次数：248 · 研究领域：Neuroscience and Neural Engineering、3D Printing in Biomedical Research、Micro and Nano Robotics

Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.