Short-term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008–2017

作者：Fan Wu, Guosheng Liu, Zhoushan Feng, Tan Xiaohua, Chuanzhong Yang, Xiaotong Ye, Yiheng Dai, Wei-Yi Liang, Xiuzhen Ye, Jing Mo, Lu Ding, Benqing Wu, Hongxiang Chen, Chi‐Wang Li, Zhe Zhang, Rong Xiao, Wei Shen, Weimin Huang, Bingyan Yang, Jun-Feng Lv, Le-Ying Huo, Huiwen Huang, Hongping Rao, Wenkang Yan, Yong Yang, Xuejun Ren, Fangfang Wang, Dong Liu, Shi-Guang Diao, Xiaoyan Liu, Qiong Meng, Yu Wang, Bin Wang, Lijuan Zhang, Yuge Huang, Dang Ao, Weizhong Li, Jieling Chen, Yanling Chen, Wei Li, Zhifeng Chen, Yueqin Ding, Xiaoyu Li, Yuefang Huang, Niyang Lin, Yangfan Cai, Shasha Han, Ya Jin, Zhong-He Wan, Yi Ban, Bo Bai, Guanghong Li, Yue-Xiu Yan, Qiliang Cui · 发表于：BMC Pediatrics · 年份：2019 · DOI：10.1186/s12887-019-1736-8 · 被引用次数：58 · 研究领域：Neonatal Respiratory Health Research、Infant Development and Preterm Care、Infant Nutrition and Health

BACKGROUND: An increasing number of extremely preterm (EP) infants have survived worldwide. However, few data have been reported from China. This study was designed to investigate the short-term outcomes of EP infants at discharge in Guangdong province. METHODS: A total of 2051 EP infants discharged from 26 neonatal intensive care units during 2008-2017 were enrolled. The data from 2008 to 2012 were collected retrospectively, and from 2013 to 2017 were collected prospectively. Their hospitalization records were reviewed. RESULTS: During 2008-2017, the mean gestational age (GA) was 26.68 ± 1.00 weeks and the mean birth weight (BW) was 935 ± 179 g. The overall survival rate at discharge was 52.5%. There were 321 infants (15.7%) died despite active treatment, and 654 infants (31.9%) died after medical care withdrawal. The survival rates increased with advancing GA and BW (p < 0.001). The annual survival rate improved from 36.2% in 2008 to 59.3% in 2017 (p < 0.001). EP infants discharged from hospitals in Guangzhou and Shenzhen cities had a higher survival rate than in others (p < 0.001). The survival rate of EP infants discharged from general hospitals was lower than in specialist hospitals (p < 0.001). The major complications were neonatal respiratory distress syndrome, 88.0% (1804 of 2051), bronchopulmonary dysplasia, 32.3% (374 of 1158), retinopathy of prematurity (any grade), 45.1% (504 of 1117), necrotizing enterocolitis (any stage), 10.1% (160 of 1588), intraventricular he...