Free breathing three-dimensional cardiac quantitative susceptibility mapping for differential cardiac chamber blood oxygenation – initial validation in patients with cardiovascular disease inclusive of direct comparison to invasive catheterization

作者：Yan Wen, Jonathan W. Weinsaft, Thanh D. Nguyen, Zhe Liu, Evelyn M. Horn, Harsimran Singh, Jonathan Kochav, Sarah Eskreis‐Winkler, Kofi Deh, Jiwon Kim, Martin R. Prince, Yi Wang, Pascal Spincemaille · 发表于：Journal of Cardiovascular Magnetic Resonance · 年份：2019 · DOI：10.1186/s12968-019-0579-7 · 被引用次数：23 · 研究领域：Advanced MRI Techniques and Applications、Atomic and Subatomic Physics Research、Cardiac Imaging and Diagnostics

Differential blood oxygenation between left (LV) and right ventricles (RV; ΔSaO 2 ) is a key index of cardiac performance; LV dysfunction yields increased RV blood pool deoxygenation. Deoxyhemoglobin increases blood magnetic susceptibility, which can be measured using an emerging cardiovascular magnetic resonance (CMR) technique, Quantitative Susceptibility Mapping (QSM) – a concept previously demonstrated in healthy subjects using a breath-hold 2D imaging approach (2D BH QSM). This study tested utility of a novel 3D free-breathing QSM approach (3D NAV QSM) in normative controls, and validated 3D NAV QSM for non-invasive ΔSaO 2 quantification in patients undergoing invasive cardiac catheterization (cath). Initial control ( n = 10) testing compared 2D BH QSM (ECG-triggered 2D gradient echo acquired at end-expiration) and 3D NAV QSM (ECG-triggered navigator gated gradient echo acquired in free breathing using a phase-ordered automatic window selection algorithm to partition data based on diaphragm position). Clinical testing was subsequently performed in patients being considered for cath, including 3D NAV QSM comparison to cine-CMR quantified LV function ( n = 39), and invasive-cath quantified ΔSaO 2 ( n = 15). QSM was acquired using 3 T scanners; analysis was blinded to comparator tests (cine-CMR, cath). 3D NAV QSM generated interpretable QSM in all controls; 2D BH QSM was successful in 6/10. Among controls in whom both pulse sequences were successful, RV/LV susceptibility di...