Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

作者：Tingting Xu, Xiangting Ge, Chunyan Lu, Wei Dai, Hongjin Chen, Zhongxiang Xiao, Liqin Wu, Guang Liang, Songmin Ying, Yali Zhang, Yuanrong Dai · 发表于：Aging · 年份：2019 · DOI：10.18632/aging.102371 · 被引用次数：52 · 研究领域：Flavonoids in Medical Research、Medicinal plant effects and applications、Natural product bioactivities and synthesis

, exhibits potent anti-inflammatory properties by inhibiting NF-κB activity. Herein, we report that Baicalein significantly reduces OVA-induced airway hyperresponsiveness (AHR), airway inflammation, serum IgE levels, mucus production, and collagen deposition around the airway. Additionally, western blot analysis and immunofluorescence assay showed that Baicalein attenuates the activation of NF-κB, which was mainly reflected by IκBα phosphorylation and degradation, p65 nuclear translocation and downstream iNOS expression. Furthermore, in human epithelial cells, Baicalein blocked TNF-α-induced NF-κB activation. Our study provides evidence that Baicalein administration alleviates the pathological changes in asthma through inactivating the NF-κB/iNOS pathway. Baicalein might be a promising potential therapy agent for patients with allergic asthma in the future.