Effect of Andrographolide and Its Analogs on Bacterial Infection: A Review

作者：Lulu Zhang, Mei Bao, Bin Liu, Heru Zhao, Yin Zhang, Xinyu Ji, Ning Zhao, Chi Zhang, Xiaojuan He, Jianfeng Yi, Yong Tan, Li Li, Cheng Lü · 发表于：Pharmacology · 年份：2019 · DOI：10.1159/000503410 · 被引用次数：93 · 研究领域：Andrographolide Research and Applications、Medicinal Plant Research、Diverse Scientific Research Studies

Bacterial infections remain the leading cause of death in children, the elderly, and immunocompromised patients. Andrographolide (AG), the main active component of the herb Andrographis paniculata, has been used for many years for anti-inflammatory and antibacterial infections. AG has an antibacterial effect on a wide variety of bacteria, which is reflected in the inhibition of bacterial pathogenic factors and the regulation of immunity to downregulate infectious inflammation caused by bacteria. In the current climate of frequently occurring antibiotic resistance, AG might be considered a promising lead for new antibacterial drug development. This review outlines the therapeutic potential of AG and its analogs in combating various bacterial infections, focusing on the mechanisms of action.