Phylodynamic analysis of HIV-1 subtypes B, C and CRF 02_AG in Senegal

作者：Fabrícia F. Nascimento, Stefan Baral, Lily Geidelberg, Christinah Mukandavire, Sheree Schwartz, Gnilane Turpin, Nguissali Turpin, Daouda Diouf, Nafissatou Leye Diouf, Karleen Coly, Coumba Touré Kane, Cheikh Tidiane Ndour, Peter Vickerman, Marie‐Claude Boily, Erik Volz · 发表于：Epidemics · 年份：2019 · DOI：10.1016/j.epidem.2019.100376 · 被引用次数：5 · 研究领域：HIV Research and Treatment、HIV/AIDS Research and Interventions、HIV, Drug Use, Sexual Risk

Surveillance of HIV epidemics in key populations and in developing countries is often challenging due to sparse, incomplete, or low-quality data. Analysis of HIV sequence data can provide an alternative source of information about epidemic history, population structure, and transmission patterns. To understand HIV-1 dynamics and transmission patterns in Senegal, we carried out model-based phylodynamic analyses using the structured-coalescent approach using HIV-1 sequence data from three different subgroups: reproductive aged males and females from the adult Senegalese population and men who have sex with other men (MSM). We fitted these phylodynamic analyses to time-scaled phylogenetic trees individually for subtypes C and CRF 02_AG, and for the combined data for subtypes B, C and CRF 02_AG. In general, the combined analysis showed a decreasing proportion of effective number of infections among all reproductive aged adults relative to MSM. However, we observed a nearly time-invariant distribution for subtype CRF 02_AG and an increasing trend for subtype C on the proportion of effective number of infections. The population attributable fraction also differed between analyses: subtype CRF 02_AG showed little contribution from MSM, while for subtype C and combined analyses this contribution was much higher. Despite observed differences, results suggested that the combination of high assortativity among MSM and the unmet HIV prevention and treatment needs represent a significant ...