Preoperative Plasma Fibrinogen and Serum Albumin Score Is an Independent Prognostic Factor for Resectable Stage II-III Gastric Cancer

作者：Menghui Wu, Yuchen Pan, Zhifang Jia, Yueqi Wang, Na Yang, Jianfeng Mu, Tianyu Zhou, Yaohua Guo, Jing Jiang, Xueyuan Cao · 发表于：Disease Markers · 年份：2019 · DOI：10.1155/2019/9060845 · 被引用次数：27 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Gastric Cancer Management and Outcomes、Nutrition and Health in Aging

Background . Radical gastrectomy with D2 lymphadenectomy is recognized as the standard treatment for resectable advanced gastric cancer. Preoperative fibrinogen and albumin measurements may bring clinical benefits in terms of providing advanced notice of a poor prognosis or recurrence in patients undergoing radical resection. The aim of this study was to identify markers that are predictive of a poor prognosis prior to surgery. Methods . Eight hundred forty-two consecutive patients who underwent curative radical gastrectomy at our hospital between 2008 and 2012 were retrospectively reviewed. Based on plasma fibrinogen and serum albumin levels, preoperative fibrinogen and albumin scores (Fib-Alb scores) were investigated, and the prognostic significance was determined. Results . The patients were classified according to a Fib-Alb score of 0 ( n = 376 ), 1 ( n = 327 ), or 2 ( n = 139 ). When the correlation between the response rate and the change in the Fib-Alb score was investigated, the response rate was significantly lower in patients with an increased Fib-Alb score than in the other patients. In the survival analysis, patients in the Fib-Alb high-score group exhibited significantly worse recurrence-free survival (RFS) ( P = 0.030 ) than patients in the other groups. A multivariate analysis using clinical stage and the change in the Fib-Alb score as covariates revealed that a change in the Fib-Alb score (Fib-Alb score 1, HR: 1.31, 95% CI: 1.03-1.66, P = ...