Locally Acquired Human Infection with Swine-Origin Influenza A(H3N2) Variant Virus, Australia, 2018

作者：Yi‐Mo Deng, Frank Wong, Natalie Spirason, Matthew Kaye, Rebecca Beazley, Migue L.l Grau, Songhua Shan, Vittoria Stevens, Kanta Subbarao, Sheena G. Sullivan, Ian Barr, Dhanasekaran Vijaykrishna · 发表于：Emerging infectious diseases · 年份：2019 · DOI：10.3201/eid2601.191144 · 被引用次数：29 · 研究领域：Influenza Virus Research Studies、Viral gastroenteritis research and epidemiology、Respiratory viral infections research

L ong-term circulation of influenza A viruses (IAVs) among swine poses a public health threat. The 2009 pandemic was caused by a reassortant swine influenza A(H1N1) virus with genes that originated from human and avian IAVs that had circulated among swine for several years (1,2). Since then, globally enhanced influenza surveillance among swine has indicated continuous introduction of human seasonal influenza viruses into swine, followed by reassortment with influenza A viruses endemic in swine (IAV-S) and persistence of many lineages in swine for several decades (3). Although IAV-S are normally limited to transmission among swine, since 2010, a total of 430 cases of human infection with swine-origin influenza A(H3N2) variant viruses (H3N2v) have been detected in the United States (4), primarily in young persons exposed to swine at agricultural fairs. Most patients had self-limited influenza-like illness (5). Recent data also suggest that IAV-S have been endemic to Australia for many decades, including viruses that were originally derived from human H3N2 viruses as early as 1968, pre-2009 seasonal H1N1 viruses, and influenza A(H1N1)pdm09 (pH1N1) viruses (