Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion

作者：Lin-Yuan Zhang, Jiaji Pan, Muyassar Mamtilahun, Yuan Zhu, Liping Wang, Ashwin Venkatesh, Rubing Shi, Xuan-Qiang Tu, Kunlin Jin, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang · 发表于：Theranostics · 年份：2019 · DOI：10.7150/thno.35841 · 被引用次数：234 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Neurological Disease Mechanisms and Treatments、Barrier Structure and Function Studies

: Our results demonstrated that aberrant activated microglia aggravate white matter injury via C3-C3aR pathway during chronic hypoperfusion. These findings indicate C3aR plays a critical role in mediating neuroinflammation and white matter injury through aberrant microglia activation, which provides a novel therapeutic target for the small vessel disease and vascular dementia.