Inkjet-printed CMOS-integrated graphene–metal oxide sensors for breath analysis

作者：Tien‐Chun Wu, Andrea De Luca, Qinyu Zhong, Xiaoxi Zhu, Osarenkhoe Ogbeide, Doo‐Seung Um, Guohua Hu, Tom Albrow‐Owen, Florin Udrea, Tawfique Hasan · 发表于：npj 2D Materials and Applications · 年份：2019 · DOI：10.1038/s41699-019-0125-3 · 被引用次数：55 · 研究领域：Gas Sensing Nanomaterials and Sensors、Advanced Sensor and Energy Harvesting Materials、Advanced Memory and Neural Computing

Abstract Early diagnosis in exhaled breath is a key technology for next-generation personal healthcare monitoring. Current chemiresistive sensors, primarily based on metal oxide (MOx) thin films, have limited applicability in such portable systems due to their high power consumption, long recovery time, poor device-to-device consistency, and baseline drifts. To address these challenges for ammonia ( $${{\rm{NH}}}_{3}$$ NH 3 ) detection in exhaled breath, a critical biomarker for a variety of kidney and liver problems, we present a formulation of a graphene–MOx functional ink-based sensing platform. We integrate our sensing layer directly onto miniaturized CMOS microhotplates (μHP) via inkjet printing, potentially enabling scalability and device-to-device performance repeatability. Using stage-by-stage temporal analysis, and a temperature-pulsed modulation (TM) strategy, we achieve ultrahigh responsivity (1500% at 10 ppm pure $${{\rm{NH}}}_{3}$$ NH 3 ), fast response and recovery time (28 and 43 s), ultralow power consumption (~6 mW), negligible baseline drift (<0.67%), excellent cross-device and cross-cycle consistency (<0.5% and <0.41% variation in responsivity) and long-term stability (<1% variation) in our graphene–zinc oxide (ZnO) formulation, outperforming conventional MOx chemiresistive sensors. We further mitigate the effect of humidity through our measurement protocols, while interference from acetone is compensated ...