Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration

作者：Qiaoqiao Lu, Jianbo Lai, Haifeng Lu, Chee H. Ng, Tingting Huang, Hua Zhang, Kaijing Ding, Zheng Wang, Jiajun Jiang, Jianbo Hu, Jing Lü, Shaojia Lu, Tingting Mou, Dandan Wang, Yanli Du, Caixi Xi, Hailong Lyu, Jingkai Chen, Yi Xu, Zhuhua Liu, Shaohua Hu · 发表于：Frontiers in Psychiatry · 年份：2019 · DOI：10.3389/fpsyt.2019.00784 · 被引用次数：82 · 研究领域：Tryptophan and brain disorders、Gut microbiota and health、Bipolar Disorder and Treatment

The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine, and evaluate their correlations with the brain and immune function. Totally 36 subjects with BD and 27 healthy controls (HCs) were recruited. The severity of depression was evaluated with the Montgomery–Asberg Depression Rating Scale (MADRS). At baseline, fecal samples were collected and analyzed by quantitative polymerase chain reaction (qPCR). T lymphocyte subsets were measured to examine immune function. Near-infrared spectroscopy (NIRS) was used to assess brain function. All BD subjects received quetiapine treatment (300 mg/d) for four weeks, following which the fecal microbiota and immune profiles were reexamined. Here, we first put forward the new concept of brain-gut coefficient of balance (B-GCB), which referred to the ratio of [oxygenated hemoglobin]/(Bifidobacteria to Enterobacteriaceae ratio), to analyze the linkage between the gut microbiota and brain function. At baseline, the CD3+ T cell proportion was positively correlated with log10 Enterobacter spp count, while the correlativity between the other bacteria and immune profiles were negative. Log10 B-GCB was positively correlated with CD3+ T cell proportion. In subjects with BD, counts of Faecalibacterium prausnitzii, Bacteroides–Prevotella group, At...