Sex Differences in Kidney Replacement Therapy Initiation and Maintenance

作者：Marlies Antlanger, Marlies Noordzij, Moniek van de Luijtgaarden, Juan Jesús Carrero, Runólfur Pálsson, Patrik Finne, Marc H. Hemmelder, Nuria Aresté-Fosalba, Anna Varberg Reisæter, Aleix Cases, Jamie P. Traynor, Reinhard Kramar, Ziad A. Massy, Kitty J. Jager, Manfred Hecking, on behalf of the ERA-EDTA Registry · 发表于：Clinical Journal of the American Society of Nephrology · 年份：2019 · DOI：10.2215/cjn.04400419 · 被引用次数：67 · 研究领域：Renal Transplantation Outcomes and Treatments、Dialysis and Renal Disease Management、Chronic Kidney Disease and Diabetes

BACKGROUND AND OBJECTIVES: More men than women undergo kidney replacement therapy (KRT) despite a larger number of women being affected by CKD. The aim of this multinational European study was to explore whether there might be historic and geographic trends in sex-specific incidence and prevalence of various KRT modalities. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We assessed sex-specific differences in KRT incidence and prevalence using data from nine countries reporting to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry for at least 40 years, during the period 1965-2015. Sex distribution data were compared with the European general population (Eurostat). Statistical methodology included basic descriptive statistics, incidence and prevalence calculations per million population (pmp), as well as their male-to-female ratios. Analyses were stratified by age group and diabetic status. RESULTS: We analyzed data from 230,378 patients receiving KRT (38% women). For all KRT modalities, the incidence and prevalence rates were consistently higher in men than women. For example, the KRT incidence increased from 8 pmp in 1965-1974 to 98 pmp in 2005-2015 in women, whereas it rose from 12 to 173 pmp in men during the same period. Male-to-female ratios, calculated for incident and prevalent KRT patients, increased with age (range 1.2-2.4), showing consistency over decades and for individual countries, despite marked changes in primary k...