Tenofovir monotherapy versus tenofovir plus entecavir combination therapy in HBeAg‐positive chronic hepatitis patients with partial virological response to entecavir

作者：Yong‐Hong Wang, Juan Liao, Dongmei Zhang, Dong‐Bo Wu, Ya‐Chao Tao, Meng‐Lan Wang, En‐Qiang Chen, Hong Tang · 发表于：Journal of Medical Virology · 年份：2019 · DOI：10.1002/jmv.25608 · 被引用次数：11 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、Drug-Induced Hepatotoxicity and Protection

AIMS: The aim of this retrospective study was to compare the efficacy and safety of tenofovir disoproxil fumarate (TDF) monotherapy and TDF + entecavir (ETV) combination therapy for chronic hepatitis B (CHB) patients with the partial virological response (PVR) to ETV. METHODS: CHB patients with PVR to ETV were switched to TDF monotherapy or TDF + ETV combination therapy. The primary efficacy outcome was a virological response (VR), and the secondary efficacy outcomes were hepatitis B e antigen (HBeAg) seroconversion and alanine aminotransferase (ALT) normalization. The primary safety outcomes were changes in serum creatinine and serum phosphorus levels. RESULTS: A total of 143 patients were investigated, including 63 patients in the TDF monotherapy group and 80 patients in the TDF + ETV combination therapy group. Baseline demographics and clinical characteristics were comparable between groups. The median age of patients was 44.5 years, and 76.2% of them were male. The VR rate in TDF + ETV group was higher than that of the TDF group at 48 weeks (88.8% vs 71.4%; P = .009). At 48 weeks, the HBeAg seroconversion rate of TDF + ETV group was higher than that of the TDF group (30% vs 15.9%; P = .049). There was no significant difference in the proportion of patients with elevated ALT in the TDF group and TDF + ETV group at 48 weeks (9.5% vs 7.5%; P = .665). After adjusting the treatment regimen, serum creatinine levels increased slightly and serum phosphorus level decreased slightl...