The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis.

作者：Anetta Lasek‐Bal, Halina Jędrzejowska–Szypułka, Sebastian Student, Aldona Warsz-Wianecka, Katarzyna Zaręba, Przemysław Puz, Wiesław Bal, Katarzyna Pawletko, Joanna Lewin‐Kowalik · 发表于：PubMed · 年份：2019 · DOI：10.26402/jpp.2019.2.04 · 被引用次数：124 · 研究领域：S100 Proteins and Annexins、Neurological Disorders and Treatments、Biomarkers in Disease Mechanisms

day of stroke. Patients with symptomatic atherosclerosis, as compared to others, were older (P = 0.003) and had higher levels of CRP, IL-6, and S100B. In each case, the differences were statistically significant. We conclude that the concentration of Il-6 and S100B on the first day of stroke are important for both the neurological status and the functional status in the acute period of the disease. Increased CRP and leukocyte count are associated with a worse prognosis regarding the course of acute stroke. The expression of pro-inflammatory agents and markers of blood-brain barrier damage in the acute phase of stroke seem to be more prominent in patients with symptomatic atherosclerosis than in patients with no clinical features of atherosclerosis. The expression of inflammatory parameters may indicate the importance of the inflammatory process starting during the early days of ischemic stroke, for the post-stroke neurological deficit.