Chemical characterization of constituents from Polygonatum cyrtonema Hua and their cytotoxic and antioxidant evaluation

作者：Ting Zeng, Yan-Ran Tang, Bin Li, Shumaila Tasneem, Han-Wen Yuan, Yanzhe Jia, Muhammad Daniyal, Nusrat Hussain, Wenmiao Wang, Wenmiao Wang, Da-Lei Zuo, Limin Gong, Bin Liu, Ji-lian Shi, Zhun Zhou, Caiyun Peng, Shu-Jin He, Wei Wang, Wei Wang · 发表于：Natural Product Research · 年份：2018 · DOI：10.1080/14786419.2018.1543682 · 被引用次数：29 · 研究领域：Phytochemistry and Biological Activities、Pharmacological Effects of Natural Compounds、Plant-based Medicinal Research

Twenty-four compounds were isolated from the roots of Polygonatum cyrtonema Hua, including a new octopamine dimer, named trans-bis(N-feruloyl)octopamine (1). The structure was established on the basis of spectroscopic and chemical methods. All the extracts and compounds were evaluated for cytotoxic and antioxidant activities by using MTT and chemiluminescence assay. The extracts showed activity against MCF-7 and HepG-2 cell lines from IC50 0.30 to 1.01 mg mL−1. Compound 3 exhibited activity against HepG-2 cell lines with IC50 8.99 μM. Compound 7 exhibited activity against Hela cell lines with IC50 2.53 μM and BGC-823 cell lines with IC50 7.77 μM. Moreover, compound 7 showed antioxidant with IC50 12 µM compared to the positive control with IC50 77 µM. Compound 16 exhibited activity against HepG-2 cell lines with IC50 1.05 μM and MCF-7 cell lines with IC50 1.89 μM. These results indicated that this plant might be potential in natural medicine and healthy food.