Ginsenoside Rb1 inhibit apoptosis in rat model of Alzheimer's disease induced by Aβ 1-40 .

作者：Yiru Wang, Yan Li, Wenyu Yang, Shiyu Gao, Jianwei Lin, Tianqi Wang, Kailiang Zhou, Haiyan Hu · 发表于：PubMed · 年份：2018 · 被引用次数：42 · 研究领域：Alzheimer's disease research and treatments、Pharmacological Effects of Natural Compounds、Ginseng Biological Effects and Applications

) for 14 consecutive days. All rats were tested for their capabilities of spatial navigation and memorization by Morris water maze. Apoptosis was tested using TUNEL staining in hippocampus neuronal cells. RT-PCR, immunohistochemical staining and western blotting were employed to confirm the expressions of Bcl-2, Bax and Cleaved Caspase-3. The results showed that Rb1 administration could prevent cognitive deficit, and significantly decreased the levels of Bax and Cleaved Caspase-3 meanwhile up regulation the level of Bcl-2 in the hippocampus. We suggest that GsRb1 may be effective for preventing or slowing the development of Alzheimer's disease, which improving cognitive and memory functions by inhibiting the levels of pro-apoptosis mediators and improving the levels of anti-apoptosis mediators in the rat brain.