Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients

作者：Hao Li, Lan Gao, Linjing Zhou, Yang Wang, Qi Li, Jin Wang, Tianjun Chen, Yongjian Zhang, Taotao Wang, Qindong Shi · 发表于：Basic & Clinical Pharmacology & Toxicology · 年份：2019 · DOI：10.1111/bcpt.13338 · 被引用次数：12 · 研究领域：Antibiotics Pharmacokinetics and Efficacy、Sepsis Diagnosis and Treatment、Antimicrobial Resistance in Staphylococcus

Abstract Teicoplanin is used for the treatment of Methicillin‐resistant Staphylococcus aureus infection. It has been demonstrated that conventional loading regimen was insufficient for teicoplanin to achieve target trough plasma concentration ( C min > 10 mg/L). Therefore, a Chinese expert group recommended an optimal loading dose regimen of teicoplanin to treat severe Gram‐positive infection. However, there was no report about the teicoplanin concentration, and the safety and efficacy of teicoplanin therapy in Chinese patients since the consensus was published. The objective of this study was to compare the teicoplanin C min and clinical response in critically ill Chinese patients after the administration of conventional or optimal loading regimen, and to reveal the potential factors that may affect teicoplanin C min in addition to loading regimen. Fifty‐five patients were retrospectively divided into two groups based on teicoplanin loading regimen: (a) CD group (conventional loading dose group, n = 18, loading dose was 400 mg); (b) OD group (optimal loading dose group, n = 37, loading dose was 800 mg). Initially, three loading doses were administered every 12 hours, while the fourth loading dose was injected 24 hours after the third dose. The maintenance dose was 400 mg (CD group) or 800 mg (OD group), respectively. The mean teicoplanin C min on day 2 and day 4 in the OD group was significantly higher than those in the CD group, which were 14.75 ± 5.93 mg/L vs 8.26 ± 4.8...