Hutchinson-Gilford Progeria Syndrome

作者：Jhon Camacho‐Cruz, Luz Dary Gutiérrez-Castañeda, Daniela Pulido, Catalina Echeverri, Betty Bernal, Luisa Bautista, Lizeth Angarita, Andrés Villamil, Laura Guarin, Vanessa Benavides, Natalia Lancheros, Juan Carlos Triviño Pardo, Monica Bautista · 发表于：Repositorio Digital de la Fundación Universitaria de Ciencias de la Salud (FUCSALUD) · 年份：2019 · DOI：10.22038/ijp.2019.42913.3592 · 被引用次数：1 · 研究领域：Nuclear Structure and Function

The Hutchinson-Gilford syndrome or progeria is a laminopathy generated by mutations that affect LMNA gene. This produces an abnormal protein named progerine which alters the formation of the cellular membrane inducing premature aging of all cells. In the present review aspects related to the pathophysiology and clinical characteristics of this syndrome are shown.