Limited Intrahost Diversity and Background Evolution Accompany 40 Years of Canine Parvovirus Host Adaptation and Spread

作者：Ian E. H. Voorhees, Hyunwook Lee, Andrew B. Allison, Robert A. López-Astacio, Laura B. Goodman, Oyebola O. Oyesola, Temidayo Olutayo Omóbòwálé, Olusegun Adesina Fagbohun, Edward J. Dubovi, Susan L. Hafenstein, Edward Charles Holmes, Colin R. Parrish · 发表于：Journal of Virology · 年份：2019 · DOI：10.1128/jvi.01162-19 · 被引用次数：85 · 研究领域：Animal Virus Infections Studies、Virus-based gene therapy research、Plant Virus Research Studies

Rapid mutation rates and correspondingly high levels of intra- and interhost diversity are often cited as key features of viruses with the capacity for emergence and sustained transmission in a new host species. However, most of this information comes from studies of RNA viruses, with relatively little known about evolutionary processes in viruses with single-stranded DNA (ssDNA) genomes. Here, we provide a unique model of virus evolution, integrating both long-term global-scale and short-term intrahost evolutionary processes of an ssDNA virus that emerged to cause a pandemic in a new host animal. Our analysis reveals that successful host jumping and sustained transmission does not necessarily depend on a high level of intrahost diversity nor result in the continued accumulation of high levels of long-term evolution change. These findings indicate that all aspects of the biology and ecology of a virus are relevant when considering their adaptability.