Comparison of Pathogenicity of Invasive and Carried Meningococcal Isolates of ST-4821 Complex in China

作者：Pengbo Guo, Bingqing Zhu, Hao Liang, Wanying Gao, Guilan Zhou, Li Xu, Yuan Gao, Jianxing Yu, Maojun Zhang, Zhujun Shao · 发表于：Infection and Immunity · 年份：2019 · DOI：10.1128/iai.00584-19 · 被引用次数：8 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、Infective Endocarditis Diagnosis and Management

= 28) belonging to group I and group II (each containing eight invasive isolates and six isolates from healthy carriers) was investigated, including adhesion, invasion, and induction of interleukin-6 (IL-6) and interleukin-8 (IL-8) release from host cells (Hep2 and A549). The invasive isolates had higher adhesion and invasion capabilities than the carried isolates in both groups. The carried cc4821 isolates in group I had stronger invasion capability than those in group II. Invasive isolates induced more IL-6 and IL-8 secretion than carried isolates in both groups. The carried cc4821 isolates stimulated higher levels of IL-8 in group I than in group II. The isolates were defined as hyperadherent and hypoadherent groups according to their adhesion ability and as hyperinvasive and hypoinvasive groups based on their invasion ability. The hyperadherent and hyperinvasive isolates mediated more IL-6 and IL-8 release than the hypoadherent and hypoinvasive isolates. There was no difference in the level of cytokine release when cc4821 isolates lost their adhesion and invasion capability after lysis. The results revealed that differences in pathogenicity existed between the two groups and that the differences were mainly determined by differences in adhesion and invasion capabilities.