Copper‐Catalyzed Sulfonyl Radical‐Enabled Regioselective Cyclization of 1,6‐Enynes

作者：Jun‐Yao Zhang, Wenhui Bao, Fu‐Hua Qin, Ke‐Wei Lei, Qiang Li, Wen‐Ting Wei · 发表于：Asian Journal of Organic Chemistry · 年份：2019 · DOI：10.1002/ajoc.201900539 · 被引用次数：17 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Radical Photochemical Reactions

Abstract A copper‐catalyzed cascade cyclization of 1,6‐enynes with sulfonyl hydrazides for producing various sulfonyl‐substituted γ ‐lactams is described. This sulfonyl radical‐enabled cyclization reaction features excellent regioselectivity, mild conditions and broad substrate scope, enabling the formation of new C−S and C−C bonds through radical sulfonylation, intramolecular cyclization and hydrogen abstraction. Moreover, relevant experiments have been carried out to probe a possible mechanism.